Christian W Gruber Selected Research

Cyclotides

12/2023	Exploring Immune Modulatory Effects of Cyclotide-Enriched Viola tricolor Preparations.
9/2022	The nature inspired peptide [T20K]-kalata B1 induces anti-tumor effects in anaplastic large cell lymphoma.
1/2022	In vitro Inhibition of HIV-1 by Cyclotide-Enriched Extracts of Viola tricolor.
11/2021	Importance of the Cyclic Cystine Knot Structural Motif for Immunosuppressive Effects of Cyclotides.
1/2021	Plant-Derived Cyclotides Modulate κ-Opioid Receptor Signaling.
1/2018	Inhibition of Breast Cancer Cell Migration by Cyclotides Isolated from Pombalia calceolaria.
1/2017	Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins.
4/2016	Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis.
3/2016	Viola plant cyclotide vigno 5 induces mitochondria-mediated apoptosis via cytochrome C release and caspases activation in cervical cancer cells.

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Christian W Gruber Research Topics

Disease

7	Neoplasms (Cancer) 09/2022 - 09/2014
6	Multiple Sclerosis 09/2022 - 01/2014
4	Inflammation (Inflammations) 04/2024 - 09/2014
3	Pain (Aches) 12/2023 - 08/2012
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 05/2015
2	Breast Neoplasms (Breast Cancer) 01/2020 - 01/2018
2	Neoplasm Metastasis (Metastasis) 01/2020 - 01/2020
1	Fibrosis (Cirrhosis) 04/2024
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 12/2023
1	Immune System Diseases (Immune Disorders) 12/2023
1	Obesity 10/2023
1	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 09/2022
1	Demyelinating Diseases (Demyelinating Disease) 09/2022
1	Lymphoma (Lymphomas) 09/2022
1	Communicable Diseases (Infectious Diseases) 01/2022
1	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 01/2022
1	Virus Diseases (Viral Diseases) 01/2022
1	Infections 01/2022
1	Visceral Pain 01/2021
1	Abdominal Pain (Pain, Abdominal) 01/2021
1	HIV Infections (HIV Infection) 01/2020
1	Rheumatoid Arthritis 01/2020
1	Asthma (Bronchial Asthma) 01/2020
1	Leukemia 01/2020
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2020
1	Triple Negative Breast Neoplasms 01/2018
1	Disease Progression 04/2016
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 04/2016
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 03/2016
1	Parkinson Disease (Parkinson's Disease) 05/2015
1	Schizophrenia (Dementia Praecox) 05/2015
1	Hypoxia (Hypoxemia) 01/2015
1	Necrosis 01/2014

Drug/Important Bio-Agent (IBA)

9	CyclotidesIBA 12/2023 - 03/2016
5	Cyclic PeptidesIBA 01/2021 - 01/2014
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 04/2024 - 01/2020
3	Peptides (Polypeptides)IBA 09/2022 - 01/2018
2	LigandsIBA 10/2023 - 01/2021
2	Interleukin-2 (IL2)IBA 09/2022 - 01/2014
2	kalata B1IBA 09/2022 - 04/2016
2	CytokinesIBA 09/2022 - 01/2014
2	Plant ExtractsIBA 01/2022 - 01/2021
2	Analgesics (Analgesic Drugs)IBA 01/2021 - 01/2021
2	Peptide Hydrolases (Proteases)FDA Link 01/2021 - 01/2019
2	Opioid Receptors (Opioid Receptor)IBA 01/2021 - 01/2021
1	CannabinoidsIBA 04/2024
1	SolventsIBA 12/2023
1	Immunosuppressive Agents (Immunosuppressants)IBA 09/2022
1	Cholecystokinin B ReceptorIBA 01/2022
1	Antiviral Agents (Antivirals)IBA 01/2022
1	NeuropeptidesIBA 01/2020
1	Oxytocin (Pitocin)FDA LinkGeneric 01/2020
1	Oxytocin Receptors (Oxytocin Receptor)IBA 01/2020
1	CXC ChemokinesIBA 01/2020
1	2,5-dichloro-4-bromophenol (B 2)IBA 01/2018
1	ethyl 2- (5- (4- chlorophenyl)pentyl)oxiran- 2- carboxylate (POCA)IBA 01/2018
1	CaspasesIBA 03/2016
1	Cytochromes c (Cytochrome c)IBA 03/2016
1	EnzymesIBA 05/2015
1	Adenosine (Adenocard)FDA LinkGeneric 01/2015
1	ras ProteinsIBA 09/2014
1	Annexin A5IBA 01/2014
1	Fluorescent Dyes (Fluorescent Probes)IBA 01/2014
1	Fluorescein (Funduscein)FDA LinkGeneric 01/2014
1	Coloring Agents (Dyes)IBA 01/2014
1	AntibodiesIBA 01/2014
1	5-(6)-carboxyfluorescein diacetate succinimidyl ester (CFSE)IBA 01/2014
1	Propidium (Propidium Iodide)IBA 01/2014
1	Plant Preparations (Preparation, Plant)IBA 08/2012

Therapy/Procedure

4	Therapeutics 12/2023 - 01/2020
1	Oral Administration 12/2023
1	Drug Therapy (Chemotherapy) 01/2020
1	Radiotherapy 01/2020